Maya Moore was the star of the show with 19 points and 13 rebounds, while team-mate Jantel Lavender also got a double-double with 15 points and 10 rebounds.
Although Sweden impressed with their throws from the charity stripe, with 13 of 15 (86.6%) compared to USA's 11 of 18 (61.1%), the victors’ accuracy from both sides of the arc proved decisive.
The USA signalled their intent early and were 16 points ahead inside the opening five minutes at 21-5.
Swedish twins Frida and Elin Eldebrink, who have driven the Scandinavians to success in this tournament, helped keep their side within sight but failed to narrow the gap.
In the second quarter the USA continued to score for fun, with Moore and Monica Wright hitting double figures before the halfway point, at which stage the score was 55-22 to the Americans.
Sweden came from behind to beat 2005 silver medalists Serbia in the semi-final, and an 8-0 scoring burst in the third quarter ignited hopes of another comeback.
But USA were having none of it.
Moore and Wright continued to dominate the scoring and fired their side into a 22-point advantage at 72-50 going into the final period.
Despite having an unassailable lead, the US didn’t take their foot off the gas, and six points from Jasmine Thomas without reply put them a full 40 points ahead at 97-57.
Amy Jaeschke sank a lay-up to make it 99 with 30 seconds left, and although they failed to break the 100-point mark, the US will be more than happy with the manner of their victory.
Greece Women’s side will play their second international, and first at home