The victory was the third of Canada's campaign and it clinched third place in Group A, with the Belgians having to settle for fourth.
Natalie Doma had 13 points to lead a balanced scoring attack with 11 of the Canada's 12 players contributing points.
The momentum swung Canada's way for good in the second quarter.
Belgium trailed 26-22 in a very tight game midway through the period when Kendel Ross made a jump shot to start an 11-0 run.
Doma then buried a jumper to cap the spurt two minutes into the second half.
The Canadians were in command the rest of the way.
Belgium briefly closed the gap to nine points at the start of the fourth quarter, but Canada were never in danger of losing their grip on the contest.
Sara Leemans had a game-high 14 points for Belgium, who were out-rebounded 52-28.
Canada repeatedly worked to get the ball inside and often drew fouls, allowing them to get to the free throw line with more frequency.
They finished 20 of 32 (64.5%) compared to 10 of 14 (71.4%) for Belgium.
Solheim Cup 2019
The Solheim Cup