In Monday's opener to the four-game series, Sandra Pavon's 20 points added to the 10 scored by Costanza Landra to inflict a crushing 81-39 win on the Chileans.
On Tuesday, Chile, minus Tatiana Gomez, who suffered tendinitis in her right knee, put up a better fight but were still powerless to prevent a 62-42 mauling.
Game three is scheduled for Wednesday with the series finishing on Thursday.
Solheim Cup 2019
The Solheim Cup